Training

 

Acquiring & Purchasing Controlled Substances

The Unit for Laboratory Animal Medicine will continue to supply controlled substances to Principal Investigators after January 1, 2010 as researchers acquire new DEA registrations for their laboratories. An extension deadline for registration has been granted until June-July 2010.  

Researcher registrants possessing a current DEA Certificate of Registration for their laboratory address must not obtain controlled substances from ULAM. Acquisition sources are listed below.

Acquisition Sources of Controlled Substances

Only researcher registrants with an active DEA Certificate of Registration and current State of Michigan controlled substance license can order controlled substances to be used in research.

The UMHS B2 Inpatient Pharmacy only stocks human pharmaceutical controlled substances, which are suitable for veterinary or animal research purposes. Telazol and euthanasia solutions must be ordered through a vendor that supplies veterinary controlled substances such as Henry Schein, MWI Veterinary, Butler Animal Health, or Vortech Pharmaceuticals. Controlled substance chemicals may be ordered through Sigma-Aldrich (analytical or chemical research-not for UCUCA approved anesthesia, analgesia, or sedation requirements unless scientifically justified).

To avoid diversion only provide a DEA registration number or a DEA Certificate of Registration copy to known vendors or the UMHS B2 Pharmacy.  

Commonly Used Controlled Substance Pharmaceutical Agents supplied by UMHS B2 Pharmacy and Vendors

DEA 222 Form Instructions

Sample DEA Form 222

DEA 222 Form Usage Log

Only the DEA registration holder may order and sign a DEA Form 222 for Schedule I or II controlled substances. A Power of Attorney may not be used. State of Michigan, Public Health Code Act 368 of 1978, Article 7,333.1773. Although, the C.F.R. (1305.05) allows for Power of Attorney this authority is not granted under Michigan law.

UMHS Inpatient Pharmacy-Level B2

  • Registrants or a Power of Attorney must complete a Researcher Controlled Substance Request Form. The Registrant DEA number and departmental short-code must be present on the form. A copy of the registrant’s current DEA Certificate of Registration (Form 223) must be presented or be on file with the UMHS B2 Inpatient Pharmacy.
  • Allow 48 hours for the pharmacy to fill and process orders.
  • When ordering Schedule II controlled substances, complete a DEA Form 222 and deliver attached copies (1 and 2) with the requisition to the UMHS Inpatient B2 Pharmacy.
  • Authorized users may sign for and pick up orders at the UMHS Inpatient B2 pharmacy Monday-Friday from 0700-1530. University of Michigan photo identification must be presented. Authorized users must verify contents of each order prior to signing for pick up. Sign and date the requisition form. File a copy of the requisition form with inventory records.
  • Secure and update all newly received controlled substances into the laboratory general inventory upon delivery. Complete copy 3, DEA Form 222 if receiving Schedule II controlled substances. Update DEA Form 222 Usage Log if utilizing to track DEA Form 222s.
  • Invoice records of controlled substances listed in Schedules I and II must be maintained separately from all of the records of the registrant.

Commercial Distributors or Vendors

The University of Michigan has negotiated University pricing and has contracts with several commercial distributors or vendors to supply controlled substance pharmaceuticals or chemicals.

  • The “Shipping To” name and laboratory address (including room number) must exactly match the address listed on the DEA Certificate of Registration (Form 223).
  • Fax or mail the order invoice with a copy of the Power of Attorney and DEA Certificate of Registration (Form 223) to vendor (if requested).
  • For Schedule II substances, complete DEA Form 222 and mail attached copies (1 and 2) to the vendor. Allow one week for processing time.
  • Controlled substance orders must use a shipping company that offers online tracking. Controlled substance orders must be delivered directly to an authorized user in the laboratory. Controlled substance packages cannot be left out in a hallway with other packages or be delivered to non-authorized users.
  • Count and verify contents of all vendor shipments received. Immediately report discrepancies or damaged items to the supplier. Sign and date the packing slip or shipping invoice. File packing slip/shipping invoice and request form with inventory records.
  • Secure and update all newly received controlled substances into the general inventory upon delivery. Complete copy 3, DEA Form 222 if receiving Schedule II controlled substances from outside vendors or suppliers. Update DEA Form 222 Usage Log if utilizing to track DEA 222 forms.
  • Invoice records of controlled substances listed in Schedule I and II must be maintained separately from all of the records of the registrant.

National Institute of Drug Abuse (NIDA)

  • Registrants can contract with the National Institute of Drug Abuse Drug Supply Program to acquire controlled substances.
  • Registrants must provide the following to NIDA for initial contracts:
    • Curriculum vitae and contact information
    • UCUCA approval letter
    • Protocol and justification including study numbers
  • Drugs to be acquired from NIDA must be listed on or added to a Departmental or Individual Registrant’s State of Michigan Controlled Substance Research License and DEA registration.
    • Allow 4-8 weeks for processing unlisted controlled substances.
    • NIDA will contact the DEA and State of Michigan for verification.
  • NIDA restricts controlled substance order quantities to less than a six month supply. Allow 30 days for processing orders.
  • NIDA orders for Schedule I or II controlled substances will require a DEA Form 222 to be completed and mailed. The address on the DEA Certificate of Registration (DEA Form 223) must match the address on DEA 222 Forms.  
  • Registrants must sign, date, and mail the enclosed “Shipment Received Notice” to NIDA upon delivery of an order. Failure to do so will result in NIDA refusing future orders or closing the account. File shipment receipts with inventory records.
  • Secure and update all newly received controlled substances into the perpetual inventory upon delivery. Complete copy 3, DEA Form 222 if receiving Schedule I or II controlled substances. Update DEA Form 222 Usage Log if utilizing to track DEA 222 forms.
  • Invoice records of controlled substances listed in Schedules I and II must be maintained separately from all of the records of the registrant.